CancerVar is a bioinformatics software tool for clinical interpretation of genetic variants by machine learning. The input to CancerVar is an annotated file generated from ANNOVAR, while the output of CancerVar is the classification of variants into 'Tier I: Variants of Strong Clinical Significance','Tier II: Variants of Potential Clinical Significance','Tier III: Variants of Unknown Clinical Significance' and 'Tier IV: Benign or Likely Benign Variants', together with detailed evidence.