CancerVar: a web server for improved evidence-based clinical interpretation for cancer somatic mutations
CancerVar is a bioinformatics software tool for clinical interpretation of somatic variants by evidence from AMP/ASCO/CAP/CGC 2017-2019 guideline. The input to CancerVar can be genomic coordinate,dbSNP ID, gene with cDNA change, gene with Protein change, while the output of CancerVar is the interpretation of variants as clinical significance: 'Tier I/Pathogenic: Variants of Strong Clinical Significance','Tier II/Likely Pathogenic: Variants of Potential Clinical Significance','Tier III: Variants of Unknown Clinical Significance' and 'Tier IV: Benign or Likely Benign Variants', together with detailed evidence.
RESTful for direct linking to specific variant
If you want to put systematic URL links on your allele registry for each variant with one click
Here are the methods:
1. Assumed your variant is located in chromosome 1, the coordinate is 115256529,build as hg19, the reference allele is T , the alternative allele is C,
then the systematic URL link will be:
"http://cancervar.wglab.org/results_new_pos.php?queryType=position&build=hg19&chr=1&pos=115256529&ref=T&alt=C ", click to test
This URL will bring you to the "Re-Interpret" page directly, also with all automated criteria.
2.Or use link to get the json file:
"http://cancervar.wglab.org/api_new.php?queryType=position&build=hg19&chr=1&pos=115256529&ref=T&alt=C", click to test